![HLA TYPE:The Key to Success in Bone Marrow](images/ti_3.gif)
Transplantation HLA Types Just as red blood cells have A, B, O types, leukocytes have HLA types.
HLA stands for human leukocyte antigens,
and the success of a transplantation depends mainly on HLA matching.
There are tens of thousands of patterns of HLA types.
Because HLA is transmitted equally from the parents,
the odds of a person's HLA matching that of his or her brothers or sisters are 1 out of 4, or 25%.
The odds of HLA matching the parents' are very slim and with unrelated people the odds are, as mentioned before, 1 out of several hundreds to many thousands.
Children can inherit 4 possible HLA types
@kexamplelThe case of one family showing why siblings have
@@a higher possibility of matching each other's HLA.
Various types of HLA
Locus A |
Locus B |
|
Locus C |
Locus D |
Locus DR |
Locus DQ |
Locus DP |
|
A1 | B5 | B40 | Cw1 | Dw1 | DR1 | DQ1 | DPw1 |
A2 | B7 | B41 | Cw2 | Dw2 | DR103 | DQ2 | DPw2 |
A203 | B703 | B42 | Cw3 | Dw3 | DR2 | DQ3 | DPw3 |
A21012 | B8 | B44(12) | Cw4 | Dw4 | DR3 | DQ4 | DPw4 |
A3 | B12 | B45(12) | Cw5 | Dw5 | DR4 | DQ5(1) | DPw5 |
A9 | B13 | B46 | Cw6 | Dw6 | DR5 | DQ6(1) | DPw6 |
A10 | B14 | B47 | Cw7 | Dw7 | DR6 | DQ7(3) | @ |
A11 | B15 | B48 | Cw8 | Dw8 | DR7 | DQ8(3) | @ |
A19 | B16 | B57(17) | Cw9(w3) | Dw9 | DR8 | DQ9(3) | @ |
A23(9) | B17 | B58(17) | Cw10(w3) | Dw10 | DR9 | @ | @ |
A24(9) | B18 | B59 | | Dw11(w7) | DR10 | | |
A2403 | B21 | . | | Dw12 | DR11(5) | | |
. | B22 | . | | . | . | | |
. | B27 | . | | . | . | | |
. | B35 | . | | . | . | | |
. | B37 | . | | . | . | | |
A66(10) | B38(16) | B75(15) | | Dw23 | DR51 | | |
A68(28) | B39(16) | B76(15) | | Dw24 | DR52 | | |
A69(28) | B3901 | B77(15) | | Dw25 | DR53 | | |
A74(19) | B3902 | B7801 | | Dw26 | | | |
Key to Success in Bone Marrow Transplantation:HLA
If the HLA does not match, the transplantation will not succeed due to rejection.
In order to carry out a successful transplantation, loci A, B and DR have to match (2 in 1 locus, 6 in total).
|